Wani takarda na baya-bayan nan da aka buga a cikin Journal of Physiology ya zurfafa shari'ar don samari na inganta tasirin motsa jiki a kan kwayoyin tsufa, ginawa a kan aikin da aka yi a baya tare da berayen da ke kusa da ƙarshen rayuwarsu na halitta wanda ke da damar yin amfani da motar motsa jiki mai nauyi.
Takardar dalla dalla-dalla, "Sa hannu na kwayoyin halitta wanda ke bayyana daidaitawar motsa jiki tare da tsufa da kuma sake fasalin wani bangare a cikin tsokar kwarangwal," ya lissafa mawallafa 16 masu haɗin gwiwa, shida daga cikinsu suna da alaƙa da U of A. Mawallafin daidai shine Kevin Murach, Mataimakin farfesa a Sashen Kiwon Lafiya na U of A, Ayyukan Dan Adam da Nishaɗi, kuma marubucin farko shine Ronald G. Jones III, Ph.D.dalibi a cikin dakin gwaje-gwaje na Dokokin Muscle Mass na Murach.
Don wannan takarda, masu binciken sun kwatanta tsofaffin berayen da ke da damar yin amfani da motar motsa jiki mai nauyi tare da berayen da suka yi reprogramming epigenetic ta hanyar bayyana abubuwan Yamanaka.
Abubuwan Yamanaka abubuwa ne na rubutun furotin guda huɗu (wanda aka sani da Oct3/4, Sox2, Klf4 da c-Myc, galibi ana rage su zuwa OKSM) waɗanda zasu iya mayar da takamaiman sel (kamar tantanin fata) zuwa ga tantanin halitta, wanda shine ƙarami kuma mafi daidaita yanayin.An ba Dr. Shinya Yamanaka lambar yabo ta Nobel a fannin ilimin halittar jiki ko magani don wannan binciken a cikin 2012. A cikin madaidaitan allurai, haifar da abubuwan Yamanaka a ko'ina cikin jiki a cikin rodents na iya inganta alamomin tsufa ta hanyar kwaikwayi daidaitawar da aka saba da ita ga mafi yawan matasa. Kwayoyin.
Daga cikin abubuwa hudu, Myc yana haifar da motsa jiki ta hanyar motsa jiki.Myc na iya zama wani abin motsa jiki da aka haifar da reprogramming a cikin tsoka, yana mai da shi mahimmin ma'anar kwatanta tsakanin sel waɗanda aka sake tsara su ta hanyar bayyana abubuwan Yamanaka da sel waɗanda aka sake tsara su ta hanyar motsa jiki - "reprogramming" a cikin yanayin ƙarshe yana nuna yadda. wani abin ƙarfafa muhalli zai iya canza damar samun dama da bayyana kwayoyin halitta.
Masu binciken sun kwatanta tsokar kwarangwal na berayen da aka ba su izinin yin motsa jiki a ƙarshen rayuwa zuwa kwarangwal na ƙwanƙwaran ƙwanƙwasa wanda ya wuce kima OKSM a cikin tsokoki, da kuma ƙwayoyin ƙwararrun ƙwararrun ƙwayoyin cuta waɗanda ke iyakance ga wuce gona da iri na kawai Myc a cikin tsokoki.
A ƙarshe, ƙungiyar ta ƙaddara cewa motsa jiki yana haɓaka bayanin martabar kwayoyin halitta daidai da shirye-shiryen ɓangaren epigenetic.Wato: motsa jiki na iya yin kwaikwayi sassa na bayanan kwayoyin halitta na tsokoki waɗanda aka fallasa su ga abubuwan Yamanaka (don haka yana nuna halayen ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin matasa).Wannan tasiri mai fa'ida na motsa jiki na iya zama wani ɓangare na takamaiman ayyuka na Myc a cikin tsoka.
Yayin da zai zama da sauƙi a ɗauka cewa wata rana za mu iya yin amfani da Myc a cikin tsoka don cimma sakamakon motsa jiki, don haka ya kare mu ainihin aiki mai wuyar gaske, Murach yayi gargadin cewa zai zama kuskuren ƙarshe don zana.
Na farko, Myc ba zai taɓa iya yin kwafin duk tasirin tasirin motsa jiki a cikin jiki ba.Haka kuma ita ce sanadin ciwace-ciwace da sankarau, don haka akwai hadurran da ke tattare da yin amfani da furcinsa.Maimakon haka, Murach yana tunanin yin amfani da Myc zai fi dacewa a yi amfani da shi azaman dabarun gwaji don fahimtar yadda za a dawo da daidaitawar motsa jiki zuwa tsohuwar tsokoki da ke nuna raguwar amsawa.Yiwuwa kuma yana iya zama wata hanya ta haɓaka martanin motsa jiki na 'yan sama jannati a cikin sifili nauyi ko kuma mutanen da ke cikin kwanciyar hankali waɗanda kawai ke da iyakacin ƙarfin motsa jiki.Myc yana da tasiri da yawa, mai kyau da mara kyau, don haka ayyana masu amfani zai iya haifar da ingantaccen magani wanda zai iya tasiri ga ɗan adam a hanya.
Murach yana ganin binciken su a matsayin ƙarin tabbatar da motsa jiki a matsayin polypill."Motsa jiki shine mafi karfi magani da muke da shi," in ji shi, kuma ya kamata a yi la'akari da lafiyar lafiyar jiki - da yiwuwar tsawaita rayuwa - magani tare da magunguna da abinci mai kyau.
Murach da Jones mawallafa a U of A sun hada da farfesa kimiyyar motsa jiki Nicholas Greene, da kuma masu bincike Francielly Morena Da Silva, Seongkyun Lim da Sabin Khadgi.
Lokacin aikawa: Maris-02-2023